Publications

See also: Google Scholar Profile

* = corresponding author

# = equal contribution

Preprints

1. Differential Kinetics of SARS-CoV-2 Proteases Revealed by a Dual-Color, BRET-based Protease Biosensor, DuProSense

Asma Fatima, Anupriya M Geethakumari, S. M. Nasir Uddin, and Kabir H Biswas*

Biorxiv – Preprint 2024 [DOI: 10.1101/2024.09.26.615113]

2. A Brighter picALuc Generated Through the Loss of a Salt Bridge Interaction

Kabir H Biswas*

Biorxiv – Preprint  2023 [DOI: 10.1101/2023.02.14.528398]

Peer-Reviewed Publications

1. Advancing Targeted Therapy for Colorectal Cancer: Harnessing Ligand-Directed Enzyme Prodrug Therapy (LDEPT) for Highly Specific Interventions 

Hend Al-Jaber, Kabir H Biswas and Layla Al-Mansoori 

Frontiers in Oncology, section Cancer Molecular Targets and Therapeutics 2025 [Accepted]

2. A BRET-based Mpro Biosensor Containing a Nanobody and Tandem Cleavage Sites shows an Increased Cleavage Rate

Anupriya M Geethakumari, Asfia Sultana, Asma Fatima, S M Nasir Uddin, Somaiya Abdulhakim, Amera Mohamed, Samiha Rahman, Khaloud Al-Buainain, Hadi M Yassine, Hebah A Al Khatib, and Kabir H Biswas*

Sensors and Actuators Reports 2025, 9:100315

3. Coevolving Residues Distant from the Ligand Binding Site are Involved in GAF Domain Function

Wesam S Ahmed, Anupriya M Geethakumari, Asfia Sultana, Anmol Tiwari, Tausif Altamash, Najla Arshad, Sandhya S Visweswariah, and Kabir H Biswas*

Communications Chemistry 2025, 8: 107

Biorxiv – Preprint  2024 [DOI: 10.1101/2024.08.07.605472]

4. Identification of a Potential Allosteric Inhibitor of SARS-CoV-2 Main Protease (Mpro)

Asma Fatima, Anupriya M Geethakumari, Wesam S Ahmed, and Kabir H Biswas*

Frontiers in Molecular Biosciences 2024, 11: 1451280

5. A Low Noise Current Readout with 124 dB Dynamic Range for Bioluminescence Sensing

Muhammad Asfandyar Awan, Khalil Ahmad, Amine Bermak, Kabir H Biswas, and Bo Wang

IEEE Biomedical Circuits and Systems (BIOCAS) 2024 [Accepted] – Conference Paper

6. An Asynchronous CMOS Current Readout with 124 dB Dynamic Range and 1 pArms Input-Referred Noise for Bioluminescence Sensing

Muhammad Asfandyar Awan, Khalil Ahmad, Amine Bermak, Kabir H Biswas, and Bo Wang

IEEE Solid-State Circuits Letters 2024, 7: 223 - 226

DOI: 10.1109/LSSC.2024.3437771

7. BRET-based Biosensors for SARS-CoV-2 Oligonucleotide Detection (BioOD) 

Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, and Kabir H Biswas*

Frontiers in Bioengineering and Biotechnology 2024, 12: 1353479

DOI: 10.3389/fbioe.2024.1353479

8. A Slow but Steady NanoLuc: R162A mutation results in a decreased, but stable, NanoLuc activity

Wesam S Ahmed, Anupriya M Geethakumari, Asfia Sultana, Asma Fatima, Angelin M Philip, S. M. Nasir Uddin, and Kabir H Biswas*

International Journal of Biological Macromolecules 2024, 269(1): 131864

DOI: 10.1016/j.ijbiomac.2024.131864

Biorxiv – Preprint  2023 [DOI: 10.1101/2023.03.05.531182]

9. Engineering β-catenin-derived peptides for α-catenin binding

S. M. Nasir Uddin#, Saad Rasool#, Anupriya M Geethakumari, Wesam S Ahmed, and Kabir H Biswas* 

Emergent Materials 2024 https://doi.org/10.1007/s42247-024-00663-8 

DOI: 10.1007/s42247-024-00663-8

10. Protegrin-2, a potential inhibitor for targeting SARS-CoV-2 main protease Mpro

Zainab Jan, Anupriya M Geethakumari, Kabir H Biswas*, and Puthen V Jithesh*

Computational and Structural Biotechnology Journal 2023, 21: 3665-71 

DOI: 10.1016/j.csbj.2023.07.020

11. Exosome Nanovesicles as Potential Biomarkers and Immune Checkpoint Signaling Modulators in Lung Cancer Microenvironment: Recent Advances and Emerging Concepts

Naushad Ahmad Khan, Mohammad Asim, Kabir H Biswas, Amani N Alansari, Harman Saman, Mohammad Zahid Sarwar, Kudaibergen Osmonoliev, Shahab Uddin 

Journal of Experimental & Clinical Cancer Research 2023, 42: 221

DOI: 10.1186/s13046-023-02753-7

12. Identification of a Potential DNA Methyl Transferase (DNMT) Inhibitor

Zainab Jan, Wesam S Ahmed, Kabir H Biswas*, Puthen V Jithesh*

Journal of Biomolecular Structure & Dynamics 2023, 42(9): 4730–4744 

DOI: 10.1080/07391102.2023.2233637

13. Regulation of Tight Junction by Cadherin Adhesion and its Implication in Inflammation and Cancer

S. M. Nasir Uddin, Asfia Sultana, Asma Fatima, Anupriya M Geethakumari, Kabir H Biswas*

In:  Bhat et al (eds) Tight Junctions in Inflammation and Cancer Springer, Cham, 2023, 49-66

DOI: 10.1007/978-981-99-2415-8

14. Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2

Angelin M Philip, Wesam S Ahmed, Kabir H Biswas*

Computational and Structural Biotechnology Journal 2023, 21: 1966

DOI: 10.1016/j.csbj.2023.02.019

15. COVID-19Base v3: Update of the Knowledgebase for Drugs and Biomedical Entities Linked to COVID-19

Syed Abdullah Basit, Rizwan Qureshi, Saleh Musleh, Reto Guler, M. Sohel Rahman, Kabir H Biswas, and Tanvir Alam 

Frontiers in Public Health 2023, 11: 1125917

DOI: 10.3389/fpubh.2023.1125917

16. Metabolomics of Diabetes and Cardiovascular Disease

Mahbuba Rahman, Rizwan Qureshi, Estevan Bruginski, Meshari Alazmi, Othman Soufan, Kabir H Biswas, and Tanvir Alam* [Book chapter]

In: Rahman M (ed) Developments in Applied Microbiology and Biotechnology Metabolomics: A Path Towards Personalized Medicine.

Elsevier Academic Press, 2022, 239-60

Available at Amazon

17. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression 

Najla Arshad, Maudry Laurent-Rolle, Wesam S Ahmed, Jack Chun-Chieh Hsu, Susan M Mitchell, Joanna Pawlak, Debrup Sengupta, Kabir H Biswas, and Peter Cresswell*

Proceedings of the National Academy of Sciences U S A 2022, 120(1): e2208525120

DOI: 10.1073/pnas.2208525120

Biorxiv – Preprint  [DOI: 10.1101/2022.05.17.492198]

18. Structure-Based Virtual Screening and Functional Validation of Potential Hit Molecules Targeting the SARS-CoV-2 Main Protease 

Balasubramanian Moovarkumudalvan, Anupriya M Geethakumari, Ramya Ramadoss, Kabir H Biswas and Borbala Mifsud

Biomolecules 2022, 12(12): 1754

DOI: 10.3390/biom12121754

19. The Evolving Role of Extracellular Vesicles (Exosomes) As Biomarkers In Traumatic Brain Injury (TBI): Clinical Perspectives And Therapeutic Implications

Naushad Ahmad Khan, Mohammad Asim, Ayman El-Menyer, Kabir H Biswas, Sandro Rizoli S, and Hassan Thani

Frontiers in Aging Neuroscience 2022, 14: 933434 

DOI: 10.3389/fnagi.2022.933434

20. A Genetically Encoded BRET-based SARS-CoV-2 Mpro Protease Activity Sensor

Anupriya M Geethakumari, Wesam S Ahmed, Saad Rasool, Asma Fatima, S. M. Nasir Uddin, Mustapha Aouida, and Kabir H Biswas*

Communications Chemistry 2022, 5: 117

DOI: 10.1038/s42004-022-00731-2

Biorxiv - Preprint [DOI: 10.1101/2022.01.31.478460]

21. Patterned Substrate of Mobile and Immobile Ligands to Probe EphA2 Receptor Clustering

Chen Zhongwen, Kabir H Biswas, and Jay T Groves

Bio-protocol 2022, 12(11):

DOI: 10.21769/BioProtoc.4434

22. Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex

Wesam S Ahmed, Angelin M Philip, and Kabir H Biswas*

Frontiers in Molecular Biosciences 2022, 9: 846996

DOI: 10.3389/fmolb.2022.846996

Stable Interaction of the UK B.1.1.7 lineage SARS-CoV-2 S1 Spike N501Y Mutant With ACE2 Revealed By Molecular Dynamics Simulation

Biorxiv - Preprint DOI: 10.1101/2021.01.07.425307

23. Understanding the mechanism of dysglycemia in a Fanconi-Bickel syndrome patient

Sanaa Sharari, Mustapha Aouida, Idris Mohammed, Basma Haris, Ajaz Ahmad Bhat, Iman Hawari, Sabah Nisar, Igor Pavlovski, Kabir H Biswas, Najeeb Syed, Selma Maacha, Jean-Charles Grivel, Maryam Saifaldeen, Johan Ericsson, and Khalid Hussain

Frontiers in Endocrinology 2022, 13: article 841788

DOI: 10.3389/fendo.2022.841788

24. Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2 

Dongmyung Oh#, Chen Zhongwen#, Kabir H Biswas, Funing Bai, Michael P Sheetz, and Jay T Groves 

Biophysical Journal 2022, 121(10):1897-1908

DOI: 10.1016/j.bpj.2022.04.015 

25. Gulf Cooperation Council Clinical Trials in the Pursuit of Medications for COVID-19

Bassam Ali Jaber, Mowafa Househ, Zubair Shah, M.Sohel Rahman, Mounir Hamdi, Kabir H Biswas, and Tanvir Alam

Informatics and Technology in Clinical Care and Public Health 2022, 9 

DOI: 10.3233/SHTI210846

26. Probe the Effect of Clustering on EphA2 Receptor Signaling Efficiency by Subcellular Control of Ligand-Receptor Mobility 

Chen Zhongwen, Dongmyung Oh, Kabir H Biswas*, Ronen Zaidel-Bar*, and Jay T Groves*

eLife 2021, 10:e67379

DOI: 10.7554/eLife.67379

27. Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence

Tausif Altamash, Wesam S Ahmed, Saad Rasool, and Kabir H Biswas*

International Journal of Molecular Sciences 2021, 22(2), 677

DOI: 10.3390/ijms22020677

28. Phosphodiesterase 5: Protein Structure, Regulation of Activity, Mechanism of Inhibition, and Therapeutic Applications of Inhibitors

Wesam S Ahmed, Anupriya M Geethakumari, and Kabir H Biswas*

Biomedicine and Pharmacotherapy  2021, 134: 111128

DOI: 10.1016/j.biopha.2020.111128 [Invited Review Article]

29. Role of actin cytoskeleton in E-cadherin-based cell-cell adhesion assembly and maintenance

Saad Rasool#, Anupriya M Geethakumari#, and Kabir H Biswas*

Journal of the Indian Institute of Science 2021, 101(1): 51-62

DOI: 10.1007/s41745-020-00214-0 [Invited Review Article]

30. Molecular mobility-mediated regulation of E-cadherin adhesion

Kabir H Biswas*

Trends in Biochemical Sciences 2020, 45(2): 163-73 

DOI: 10.1016/j.tibs.2019.10.012 [Invited Review Article]

31. A Molecular Assembly Phase Transition and Kinetic Proofreading Modulate Ras Activation by SOS 

William Y. C. Huang, Steven Alvarez, Yasushi Kondo, Young Kwang Lee, Jean K. Chung, Hiu Yue Monatrice Lam, Kabir H. Biswas, John Kuriyan, and Jay T. Groves

Science 2019, 363(6431): 1098-1103   [PDF]

DOI: 10.1126/science.aau5721

32. Hybrid Live Cell-Supported Membrane Interfaces for Signaling Studies 

Kabir H Biswas* and Jay T Groves* 

Annual Review of Biophysics 2019, 48: 537-62    [PDF]

DOI: 10.1146/annurev-biophys-070317-033330 [Invited Review Article]

33. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers 

Liulin Wang#, Kabir H. Biswas#, Bo Kyeong Yoon, Lisa M. Kawakami, Soohyun Park, Jay T. Groves, Lin Li*, Wei Huang, and Nam-Joon Cho*

Langmuir 2018, 34(36): 10764-73   [PDF]

DOI: 10.1021/acs.langmuir.8b01348

34. Fabrication Of Multicomponent, Spatially Segregated DNA And Protein Functionalized SupportedMembrane Microarray

Kabir H Biswas*, Nam-Joon Cho, and Jay T Groves* 

Langmuir 2018, 34(33): 9781-8   [PDF] 

DOI: 10.1021/acs.langmuir.8b01364

35. Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility

Chen Zhongwen, Dongmyung Oh, Kabir H Biswas, Cheng-han Yu, Ronen Zaidel-Bar, and Jay T Groves

Proceedings of the National Academy of Sciences U S A 2018, 115(25): E5696-E5705   [PDF]

DOI: 10.1073/pnas.1719961115

36. Regulation of α-catenin conformation at cadherin adhesions

Kabir H Biswas*

Journal of Biomechanical Science & Engineering 2018, 13(4):17-00699   [PDF] 

DOI: 10.1299/jbse.17-00699 [Invited Review Article]

37. Multicomponent Supported Membrane Microarray for Monitoring Spatially Resolved Cellular Signaling Reactions

Kabir H Biswas*, Chen Zhongwen, Alok Kumar Dubey, Dongmyung Oh, and Jay T Groves*

Advanced Biosystems 2018, 2(4): 1800015   [PDF]

DOI: 10.1002/adbi.201800015

38. Interfacial forces dictate pathway of phospholipid vesicle adsorption and spontaneous rupture onto silicon dioxide surfaces

Kabir H Biswas, Joshua A. Jackman, Jae Hyeon Park, Jay T. Groves, and Nam-Joon Cho

Langmuir 2018, 34(4), 1775-82   [PDF]

DOI: 10.1021/acs.langmuir.7b03799

39. Spatial and mechanical aspects of signal transduction in the cell membrane

Kabir H Biswas* and Jay T Groves*

In: Bassereau P., Sens P. (eds) Physics of Biological Membranes. Springer, Cham, 2018, 537-60 (Book chapter)   [PDF]

DOI: 10.1007/978-3-030-00630-3_19 [Invited Book Chapter]

40. Buffer NaCl concentration regulates Renilla luciferase activity and ligand-induced conformational changes in the BRET-based PDE5 sensor

Kabir H Biswas* and Sandhya S Visweswariah*

Matters 2017   [PDF]

DOI: 10.19185/matters.201702000015

41. Dynamic cellular interactions with extracellular matrix triggered by biomechanical tuning of low-rigidity, supported lipid membranes

Setareh Vafaei, Seyed R. Tabaei, Kabir H Biswas, Jay T Groves, and Nam-Joon Cho

Advanced Healthcare Materials 2017, 6(10): 1700243-n/a   [PDF] 

DOI: 10.1002/adhm.201700243

42. Early events in the assembly of E-cadherin adhesions

Kabir H Biswas* and Ronen  Zaidel-Bar* 

Experimental Cell Research 2017, 358(1): 14-9   [PDF]

DOI: 10.1016/j.yexcr.2017.02.037 [Invited Review Article]

43. Allosteric regulation of proteins: a historical perspective on the development of concepts and techniques

Kabir H Biswas*

Resonance 2017, 22(1): 37-50   [PDF]

DOI: 10.1007/s12045-017-0431-z

44. Sustained α-catenin activation at E-cadherin junctions in the absence of mechanical force

Kabir H Biswas*, Kevin L. Hartman, Ronen Zaidel-Bar*, and Jay T Groves*

Biophysical Journal 2016, 111: 1044-52   [PDF]

DOI: 10.1016/j.bpj.2016.06.027

See also:

Force Bistability in Adhesion Switch

F1000Prime recommendation

45. A microbead supported membrane-based fluorescence imaging assay reveals intermembrane receptor-ligand complex dimension with nanometer precision

Kabir H Biswas* and Jay T Groves*

Langmuir 2016, 32(26): 6775–80   [PDF]

DOI: 10.1021/acs.langmuir.6b01377

46. Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Cheng-han Yu, Nisha Bte Mohd Rafiq, Fakun Cao, Yuhuan Zhou, Anitha Krishnasamy, Kabir H Biswas, Andrea Ravasio, Zhongwen Chen, Yu-Hsiu Wang, Keiko Kawauchi, Gareth E. Jones, and Michael P. Sheetz

Nature Communications 2016, 6:8672   [PDF]

DOI: 10.1038/ncomms9672

47. E-cadherin junction formation involves an active kinetic nucleation process

Kabir H Biswas#, Kevin L. Hartman#, Cheng-han Yu, Oliver J. Harrison, Hang Song, Adam W. Smith, William Y. C. Huang, Wan-Chen Lin, Zhenhuan Guo, Anup Padmanabhan, Sergey M. Troyanovsky, Michael L. Dustin, Lawrence Shapiro, Barry Honig, Ronen Zaidel-Bar, and Jay T. Groves

Proceedings of the National Academy of Sciences U S A 2015, 112(35):10932-7   [PDF]

DOI: 10.1073/pnas.1513775112

See also:

E-cadherin mobility regulates adhesion formation

48. Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2

Kabir H Biswas*, Suguna Badireddy, Abinaya Rajendran, Ganesh S Anand, and Sandhya S Visweswariah*

PeerJ 2015, 3:e882; DOI 10.7717/peerj.882   [PDF]

DOI: 10.7717/peerj.882

49. Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation

Torunn Fiskerstrand, Najla Arshad, Bjørn Ivar Haukanes, Rune Rose Tronstad, Khanh Do-Cong Pham, Stefan Johansson, Bjarte Håvik, Siv L. Tønder, Shawn E. Levy, Damien Brackman, Helge Boman, Kabir H Biswas, Jaran Apold, Nils Hovdenak, Sandhya S Visweswariah, and Per M. Knappskog

New England Journal of Medicine 2012, 366(17):1586-95   [PDF]

DOI: 10.1056/NEJMoa1110132

See also:

Familial diarrhea syndrome

Genetic mutation found in familial chronic diarrhea syndrome

Chromosome 12 Mutation Linked to Familial Diarrhea

GUCY2C gene mutation leads to familial diarrhea syndrome

Gene May Play Role in Frequent Diarrhea

50. Distinct Allostery Induced in the Cyclic GMP-binding, Cyclin GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil and Metal Ions

Kabir H Biswas and Sandhya S Visweswariah

Journal of Biological Chemistry 2011, 286(10): 8545-54   [PDF]

DOI: 10.1074/jbc.M110.193185

51. The Linker Region in Receptor Guanylyl Cyclases is a Key Regulatory Module: Mutational Analysis of Guanylyl Cyclase C

Sayanti Saha, Kabir H Biswas, Chandana Kondapalli, Nishitha Isloor, and Sandhya S Visweswariah

Journal of Biological Chemistry 2009, 284(40): 27135-45   [PDF]

DOI: 10.1074/jbc.M109.020032s

52. The Evolution of Guanylyl Cyclases as Multidomain Proteins: Conserved Features of kinase-cyclase domain fusions

Kabir H Biswas, Avinash R Shenoy, Anindya Dutta, and Sandhya S Visweswariah

Journal of Molecular Evolution 2009, 68(6):587-602   [PDF]

DOI: 10.1007/s00239-009-9242-5

53. The GAF Domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP

Kabir H Biswas, Shailaja Sopory, and Sandhya S Visweswariah

Biochemistry 2008, 47(11): 3534-43   [PDF]

DOI: 10.1021/bi702025w

Non-peer Reviewed Publications

1. Maté or Energy Drinks: Are There Health Consequences?

HBKU

2. Vaccine Doses: A Changing  Medical Approach

TRT World | TRT Arabic | HBKU

3. Will mutations cause the weakening of coronavirus making it fade and disappear?

Al Jazeera Arabic

4. Vaccination is Vital Not Only for Individual Health but Also to Thwart the Pandemic

CHLS/HBKU

5. Review 1: " Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera"

Rapid Reviews: COVID-19

6. Oped: Tackling Childhood Asthma: the View from Qatar

Qatar Tribune | Gulf Times | The Peninsula | MENAFN

7. Oped: Why Scepticism is Integral to Science, But Not All of it is Good

Silicon Republic

8. Oped: How Dogs Could Help In Detecting COVID-19 Carriers In The Future

Qatar Tribune | Gulf Times;