Publications

See also: Google Scholar Profile

* = corresponding author

# = equal contribution

Preprints

45. A Slow but Steady NanoLuc: R162A mutation results in a decreased, but stable, NanoLuc activity

Ahmed WS, Geethakumari AM, Sultana A, Fatima A, Philip AM, Nasiruddin S M , Biswas KH*

Biorxiv – Preprint  2023 [DOI: 10.1101/2023.03.05.531182]

44. A Brighter picALuc Generated Through the Loss of a Salt Bridge Interaction

Biswas KH*

Biorxiv – Preprint  2023 [DOI: 10.1101/2023.02.14.528398]

Peer-Reviewed Publications

44. Protegrin-2, a potential inhibitor for targeting SARS-CoV-2 main protease Mpro

Jan Z, Geethakumari AM, Biswas KH*, Jithesh PV*

Computational and Structural Biotechnology Journal 2023, 21: 3665-71 

DOI: 10.1016/j.csbj.2023.07.020

43. Exosome Nanovesicles as Potential Biomarkers and Immune Checkpoint Signaling Modulators in Lung Cancer Microenvironment: Recent Advances and Emerging Concepts

 Khan NA, Asim M, Biswas KH, Al-Ansari A, Saman H, Sarwar MZ, Osmonoliev K, Uddin S

 Journal of Experimental & Clinical Cancer Research 2023, 42: 221

DOI: 10.1186/s13046-023-02753-7

42. Identification of a Potential DNA Methyl Transferase (DNMT) Inhibitor

Jan Z, Ahmed WS, Biswas KH*, Jithesh PV*

Journal of Biomolecular Structure & Dynamics 2023 

DOI: 10.1080/07391102.2023.2233637

41. Regulation of Tight Junction by Cadherin Adhesion and its Implication in Inflammation and Cancer

Uddin SM Nasir, Sultana A, Fatima A, Geethakumari AM, Biswas KH*

In:  Bhat et al (eds) Tight Junctions in Inflammation and Cancer Springer, Cham, 2023, 49-66

DOI: 10.1007/978-981-99-2415-8

40. Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2

Philip AM, Ahmed WS, Biswas KH*

Computational and Structural Biotechnology Journal 2023, 21: 1966

DOI: 10.1016/j.csbj.2023.02.019

39. COVID-19Base v3: Update of the Knowledgebase for Drugs and Biomedical Entities Linked to COVID-19

Basit SA, Qureshi R, Musleh S, Guler R, Rahman MS, Biswas KH, Alam T 

Frontiers in Public Health 2023, 11: 1125917

DOI: 10.3389/fpubh.2023.1125917

38. Metabolomics of Diabetes and Cardiovascular disease

Rahman M, Qureshi R, Bruginski E, Alazmi M, Soufan O, Biswas KH, Alam T [Book chapter]

In: Rahman M (ed) Developments in Applied Microbiology and Biotechnology Metabolomics: A Path Towards Personalized Medicine. Elsevier Academic Press, 2022, 239-60

Available at Amazon

37. SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expression 

Arshad N, Laurent-Rolle M, Ahmed WS, Hsu JC-C, Mitchell SM, Pawlak J, Sengupta D, Biswas KH, Cresswell P

Proceedings of the National Academy of Sciences U S A 2022, 120(1): e2208525120

DOI: 10.1073/pnas.2208525120

Biorxiv – Preprint  [DOI: 10.1101/2022.05.17.492198]

36. Structure-Based Virtual Screening and Functional Validation of Potential Hit Molecules Targeting the SARS-CoV-2 Main Protease 

Moovarkumudalvan B, Geethakumari AM, Ramadoss R, Biswas KH and Mifsud B

Biomolecules 2022, 12(12): 1754

DOI: 10.3390/biom12121754

35. The Evolving Role of Extracellular Vesicles (Exosomes) As Biomarkers In Traumatic Brain Injury (TBI): Clinical Perspectives And Therapeutic Implications

Khan NA, Asim M, Menyer AE, Biswas KH, Rizoli S, Thani HA 

Frontiers in Aging Neuroscience 2022, 14: 933434 

DOI: 10.3389/fnagi.2022.933434

34. A Genetically Encoded BRET-based SARS-CoV-2 Mpro Protease Activity Sensor

Geethakumari AM, Ahmed WS, Rasool S, Fatima A, Uddin SM Nasir, Aouida M, Biswas KH*

Communications Chemistry 2022, 5: 117

DOI: 10.1038/s42004-022-00731-2

Biorxiv - Preprint [DOI: 10.1101/2022.01.31.478460]

33. Patterned Substrate of Mobile and Immobile Ligands to Probe EphA2 Receptor Clustering

Chen Z, Biswas KH, Groves JT

Bio-protocol 2022, 12(11):

DOI: 10.21769/BioProtoc.4434

32. Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex

Ahmed W, Philip AM, Biswas KH*

Frontiers in Molecular Biosciences 2022, 9: 846996

DOI: 10.3389/fmolb.2022.846996

Stable Interaction of the UK B.1.1.7 lineage SARS-CoV-2 S1 Spike N501Y Mutant With ACE2 Revealed By Molecular Dynamics Simulation

Biorxiv - Preprint DOI: 10.1101/2021.01.07.425307

31. Understanding the mechanism of dysglycemia in a Fanconi-Bickel syndrome patient

Sharari S, Saifaldeen M, Mohammed I, Haris B, Bhat AA, Hawari I, Nisar S, Pavlovski I, Biswas KH, Almabrazi H, Syed N, Maacha S, Grivel JC, Aouida M, Ericsson J, Hussain K

Frontiers in Endocrinology 2022, 13: article 841788

DOI: 10.3389/fendo.2022.841788

30. Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2 

Oh D #, Chen Z#, Biswas KH, Bai F, Sheetz MP, Groves JT 

Biophysical Journal 2022, 121(10):1897-1908

DOI: 10.1016/j.bpj.2022.04.015 

29. Gulf Cooperation Council Clinical Trials in the Pursuit of Medications for COVID-19

Jaber BA, Househ M, Shah Z, Rahman MS, Hamdi M, Biswas KH, Alam T

Informatics and Technology in Clinical Care and Public Health 2022, 9 

DOI: 10.3233/SHTI210846

28. Probe the Effect of Clustering on EphA2 Receptor Signaling Efficiency by Subcellular Control of Ligand-Receptor Mobility 

Chen Z, Oh D, Biswas KH*, Zaidel-Bar R*, Groves JT*

eLife 2021, 10:e67379

DOI: 10.7554/eLife.67379

27. Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence

Altamash T, Ahmed W, Rasool S, Biswas KH*

International Journal of Molecular Sciences 2021, 22(2), 677

DOI: 10.3390/ijms22020677

26. Phosphodiesterase 5: Protein Structure, Regulation of Activity, Mechanism of Inhibition, and Therapeutic Applications of Inhibitors

Ahmed W, Geethakumari AM, Biswas KH*

Biomedicine and Pharmacotherapy  2021, 134: 111128

DOI: 10.1016/j.biopha.2020.111128 [Invited Review Article]

25. Role of actin cytoskeleton in E-cadherin-based cell-cell adhesion assembly and maintenance

Rasool S#, Geethakumari AM#, Biswas KH*

Journal of the Indian Institute of Science 2021, 101(1): 51-62

DOI: 10.1007/s41745-020-00214-0 [Invited Review Article]

24. Molecular mobility-mediated regulation of E-cadherin adhesion

Biswas KH*

Trends in Biochemical Sciences 2020, 45(2): 163-73 

DOI: 10.1016/j.tibs.2019.10.012 [Invited Review Article]

23. A Molecular Assembly Phase Transition and Kinetic Proofreading Modulate Ras Activation by SOS 

Huang WYC, Alvarez S, Kondo Y, Lee YK, Chung JK, Lam HYM, Biswas KH, Kuriyan J, Groves JT 

Science 2019, 363(6431): 1098-1103   [PDF]

DOI: 10.1126/science.aau5721

22. Hybrid Live Cell-Supported Membrane Interfaces for Signaling Studies 

Biswas KH*, Groves JT* 

Annual Review of Biophysics 2019, 48: 537-62    [PDF]

DOI: 10.1146/annurev-biophys-070317-033330 [Invited Review Article]

Invited review article

21. Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers 

Wang L#, Biswas KH#, Kawakami L, Park S, Yoon BK, Cho N-J

Langmuir 2018, 34(36): 10764-73   [PDF]

DOI: 10.1021/acs.langmuir.8b01348

20. Fabrication Of Multicomponent, Spatially Segregated DNA And Protein Functionalized SupportedMembrane Microarray

Biswas KH*, Cho N-J, Groves JT* 

Langmuir 2018, 34(33): 9781-8   [PDF] 

DOI: 10.1021/acs.langmuir.8b01364

19. Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility

Chen Z#, Oh D#, Biswas KH, Yu C-H, Zaidel-Bar R, Groves JT

Proceedings of the National Academy of Sciences U S A 2018, 115(25): E5696-E5705   [PDF]

DOI: 10.1073/pnas.1719961115

18. Regulation of α-catenin conformation at cadherin adhesions

Biswas KH*

Journal of Biomechanical Science & Engineering 2018, 13(4):17-00699   [PDF] 

DOI: 10.1299/jbse.17-00699 [Invited Review Article]

17. Multicomponent Supported Membrane Microarray for Monitoring Spatially Resolved Cellular Signaling Reactions

Biswas KH*, Chen Z, Dubey AK, Oh D, Groves JT*

Advanced Biosystems 2018, 2(4): 1800015   [PDF]

DOI: 10.1002/adbi.201800015

16. Interfacial forces dictate pathway of phospholipid vesicle adsorption and spontaneous rupture onto silicon dioxide surfaces

Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ

Langmuir 2018, 34(4), 1775-82   [PDF]

DOI: 10.1021/acs.langmuir.7b03799

15. Spatial and mechanical aspects of signal transduction in the cell membrane

Biswas KH*, Groves JT*

In: Bassereau P., Sens P. (eds) Physics of Biological Membranes. Springer, Cham, 2018, 537-60 (Book chapter)   [PDF]

DOI: 10.1007/978-3-030-00630-3_19 [Invited Book Chapter]

14. Buffer NaCl concentration regulates Renilla luciferase activity and ligand-induced conformational changes in the BRET-based PDE5 sensor

Biswas KH*, Viswesweriah SS*

Matters 2017   [PDF]

DOI: 10.19185/matters.201702000015

13. Dynamic cellular interactions with extracellular matrix triggered by biomechanical tuning of low-rigidity, supported lipid membranes

Vafaei S, Tabaei SR, Biswas KH, Groves JT, Cho NJ

Advanced Healthcare Materials 2017, 6(10): 1700243-n/a   [PDF] 

DOI: 10.1002/adhm.201700243

12. Early events in the assembly of E-cadherin adhesions

Biswas KH* and Zaidel-Bar R* 

Experimental Cell Research 2017, 358(1): 14-9   [PDF]

DOI: 10.1016/j.yexcr.2017.02.037 [Invited Review Article]

11. Allosteric regulation of proteins: a historical perspective on the development of concepts and techniques

Biswas KH*

Resonance 2017, 22(1): 37-50   [PDF]

DOI: 10.1007/s12045-017-0431-z

10. Sustained α-catenin activation at E-cadherin junctions in the absence of mechanical force

Biswas KH*, Hartman KL, Zaidel-Bar R*, Groves JT*

Biophysical Journal 2016, 111: 1044-52   [PDF]

DOI: 10.1016/j.bpj.2016.06.027

See also:

Force Bistability in Adhesion Switch

F1000Prime recommendation

9. A microbead supported membrane-based fluorescence imaging assay reveals intermembrane receptor-ligand complex dimension with nanometer precision

Biswas KH*, Groves JT*

Langmuir 2016, 32(26): 6775–80   [PDF]

DOI: 10.1021/acs.langmuir.6b01377

8. Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Yu C-h, Rafiq NBM, Cao F, Zhou Y, Krishnasamy A, Biswas KH, Ravasio A, Chen Z, Wang Y-H, Kawauchi K, Jones GE, Sheetz MP

Nature Communications 2016, 6:8672   [PDF]

DOI: 10.1038/ncomms9672

7. E-cadherin junction formation involves an active kinetic nucleation process

Biswas KH#, Hartman KL#, Yu C-h, Harrison OJ, Song H, Smith AW, Huang WYC, Lin W-C, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, Groves JT

Proceedings of the National Academy of Sciences U S A 2015, 112(35):10932-7   [PDF]

DOI: 10.1073/pnas.1513775112

See also:

         E-cadherin mobility regulates adhesion formation

6. Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2

Biswas KH*, Badireddy S, Rajendran A, Anand GS and Viswesweriah SS*

PeerJ 2015, 3:e882; DOI 10.7717/peerj.882   [PDF]

DOI: 10.7717/peerj.882

5. Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation

Finkerstrand T, Arshad N, Haukanes BI, Tronstad RR, Pham KDC, Johansson S, Havik B, Tonder SL, Levy SE, Brackman D, Boman H, Biswas KH, Apold J, Hovdenak N, Visweswariah SS and Knappskog PM

New England Journal of Medicine 2012, 366(17):1586-95   [PDF]

DOI: 10.1056/NEJMoa1110132

See also:

Familial diarrhea syndrome

Genetic mutation found in familial chronic diarrhea syndrome

Chromosome 12 Mutation Linked to Familial Diarrhea

GUCY2C gene mutation leads to familial diarrhea syndrome

Gene May Play Role in Frequent Diarrhea

4. Distinct Allostery Induced in the Cyclic GMP-binding, Cyclin GMP-specific Phosphodiesterase (PDE5) by Cyclic GMP, Sildenafil and Metal Ions

Biswas KH and Visweswariah SS

Journal of Biological Chemistry 2011, 286(10): 8545-54   [PDF]

DOI: 10.1074/jbc.M110.193185

3. The Linker Region in Receptor Guanylyl Cyclases is a Key Regulatory Module: Mutational Analysis of Guanylyl Cyclase C

Saha S, Biswas KH, Kondanapallic C, Isloor N and Visweswariah SS

Journal of Biological Chemistry 2009, 284(40): 27135-45   [PDF]

DOI: 10.1074/jbc.M109.020032s                                                   

2. The Evolution of Guanylyl Cyclases as Multidomain Proteins: Conserved Features of kinase-cyclase domain fusions

Biswas KH, Shenoy AR, Dutta A and Visweswariah SS

Journal of Molecular Evolution 2009, 68(6):587-602   [PDF]

DOI: 10.1007/s00239-009-9242-5

1. The GAF Domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP

Biswas KH, Sopory S and Visweswariah SS

Biochemistry 2008, 47(11): 3534-43   [PDF]

DOI: 10.1021/bi702025w

Non-peer Reviewed Publications

8. Maté or Energy Drinks: Are There Health Consequences?

    HBKU

7. Vaccine Doses: A Changing  Medical Approach

TRT World | TRT Arabic | HBKU

6. Will mutations cause the weakening of coronavirus making it fade and disappear?

    Al Jazeera Arabic

5. Vaccination is Vital Not Only for Individual Health but Also to Thwart the Pandemic

    CHLS/HBKU

4. Review 1: " Neutralization of N501Y mutant SARS-CoV-2 by BNT162b2 vaccine-elicited sera"

    Rapid Reviews: COVID-19

3. Oped: Tackling Childhood Asthma: the View from Qatar

Qatar Tribune | Gulf Times | The Peninsula | MENAFN

2. Oped: Why Scepticism is Integral to Science, But Not All of it is Good

Silicon Republic

1. Oped: How Dogs Could Help In Detecting COVID-19 Carriers In The Future

Qatar Tribune | Gulf Times;