MEmBERS

PRINCIPAl INVESTIGATOR

Dr. Kabir H Biswas

Dr. Biswas is broadly interested in designing biointerfaces and biosensors for the purpose of understanding and controlling cellular signaling with an emphasis on the role of spatial organization and mechanical regulation of signaling proteins. He employs a variety of biophysical and materials approaches including nano- and micropatterning techniques to design supported membrane-based patterned substrates and genetically encoded, bioluminescence resonance energy transfer (BRET)-based sensors. Traditional biochemical and cellular assays provide some understanding of cellular signaling including the identity of the proteins involved in a particular pathway, and their biochemical transformations or interacting partners. However, these techniques are often unsuitable for dissecting the role of spatial organization or mechanical regulation of signaling proteins, features that have been recently revealed to be of prime importance. Some examples of such regulation include the molecular mobility-dependent cadherin adhesion formation, spatial localization dependent T-cell receptor signaling and substrate rigidity dependent integrin signaling. Insights gained from these studies will aid in the development of alternative, novel therapeutic avenues for diseases such as cancer.


Postocdoctoral Fellows

[1] Dr. Anupriya MG, CHLS, HBKU (Spring 2020 - )

Publications:

  1. Phosphodiesterase 5: Protein Structure, Regulation of Activity, Mechanism of Inhibition, and Therapeutic Applications of Inhibitors, Ahmed W, Geethakumari AM, Biswas KH*, Biomedicine and Pharmacotherapy 2021, 134: 111128 DOI: 10.1016/j.biopha.2020.111128 [Invited Review Article]

  2. Role of actin cytoskeleton in E-cadherin-based cell-cell adhesion assembly and maintenance, Rasool S#, Geethakumari AM#, Biswas KH* Journal of the Indian Institute of Science 2021, 101(1): 51-62 DOI: 10.1007/s41745-020-00214-0 [Invited Review Article]



Graduate students

[4] S M Nasiruddin, PhD student, BBS, CHLS, HBKU (Spring 2021 - ongoing)


[3] Angelin Philip, PhD student, GPM, CHLS, HBKU (Fall 2020 - ongoing)


[2] Asfia Sultana, PhD student, BBS, CHLS, HBKU (Fall 2020 - ongoing)


[1] Wesam Ahmed, PhD student, BBS, CHLS, HBKU (Spring 2020 - ongoing)

Publications:

  1. Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence, Altamash T, Ahmed W, Rasool S, Biswas KH* International Journal of Molecular Sciences 2021, 22(2), 677 DOI: 10.3390/ijms22020677

  2. Phosphodiesterase 5: Protein Structure, Regulation of Activity, Mechanism of Inhibition, and Therapeutic Applications of Inhibitors, Ahmed W, Geethakumari AM, Biswas KH*, Biomedicine and Pharmacotherapy 2021, 134: 111128 DOI: 10.1016/j.biopha.2020.111128 [Invited Review Article]

Positions are available for graduate students to work on exciting projects related to mechanisms of cell signaling using a variety of biophysical and materials engineering approaches. Graduate students at HBKU who find our work interesting may get in touch with Dr. Biswas directly.

Masters students

[2] Asma Fatima, MS student, BBS, CHLS, HBKU (Fall 2021 - ongoing)


[1] Saad Rasool, MS student, GPM, CHLS, HBKU (Fall 2020 - ongoing)

Publications:

  1. Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence, Altamash T, Ahmed W, Rasool S, Biswas KH* International Journal of Molecular Sciences 2021, 22(2), 677 DOI: 10.3390/ijms22020677

  2. Role of actin cytoskeleton in E-cadherin-based cell-cell adhesion assembly and maintenance, Rasool S#, Geethakumari AM#, Biswas KH* Journal of the Indian Institute of Science 2021, 101(1): 51-62 DOI: 10.1007/s41745-020-00214-0 [Invited Review Article]


Masters student at HBKU interested in our laboratory may write to Dr. Biswas directly.

ROTATION students

[5] Asfia Sultana, PhD student, BBS, CHLS, HBKU (Fall 2020)

[4] Debora Nicaretta Mattei, MS student, BBS, CHLS, HBKU (Fall 2020)

[3] Wesam Ahmed, PhD student, BBS, CHLS, HBKU (Fall 2019)

[2] Lutfiye Yildiz Ozer, PhD student, BBS, CHLS, HBKU (Fall 2019)

[1] Nada Mohamed Kafour, MS student, BBS, CHLS, HBKU (Fall 2019)

ALUMNI

[4] Debora Nicaretta Mattei, MS student (rotation), BBS, CHLS, HBKU (Fall 2020)

[3] Dr. Tausif Altamash, Postdoctoral Fellow, CHLS, HBKU (Fall 2019 - Spring 2020)

[2] Lutfiye Yildiz Ozer, PhD student (rotation), BBS, CHLS, HBKU (Fall 2019)

[1] Nada Mohamed Kafour, MS student (rotation), BBS, CHLS, HBKU (Fall 2019)