MEmBERS
PRINCIPAl INVESTIGATOR
Dr. Kabir H Biswas
Dr. Biswas is broadly interested in designing biointerfaces and biosensors for the purpose of understanding and controlling cellular signaling with an emphasis on the role of spatial organization and mechanical regulation of signaling proteins. He employs a variety of biophysical and materials approaches including nano- and micropatterning techniques to design supported membrane-based patterned substrates and genetically encoded, bioluminescence resonance energy transfer (BRET)-based sensors. Traditional biochemical and cellular assays provide some understanding of cellular signaling including the identity of the proteins involved in a particular pathway, and their biochemical transformations or interacting partners. However, these techniques are often unsuitable for dissecting the role of the spatial organization or mechanical regulation of signaling proteins, features that have been recently revealed to be of prime importance. Some examples of such regulation include molecular mobility-dependent cadherin adhesion formation, spatial localization-dependent T-cell receptor signaling, and substrate rigidity-dependent integrin signaling. Insights gained from these studies will aid in the development of alternative, novel therapeutic avenues for diseases such as cancer.
Postdoctoral Fellow
[1] Dr. Anupriya M Geethakumari, CHLS, HBKU (Spring 2020 - )
Publications from BiswasLab at CHLS/HBKU:
Uddin et al, Tight Junctions in Inflammation and Cancer [Book chapter]
Sultana et al, Front Bioeng Biotechnol, 2024
Graduate students
Current
[5] Asma Fatima, PhD student, BBS, CHLS, HBKU (Fall 2022 - ongoing)
Publications from BiswasLab at CHLS/HBKU:
[4] S M Nasiruddin, PhD student, BBS, CHLS, HBKU (Spring 2021 - ongoing)
Publications from BiswasLab at CHLS/HBKU:
Former
[3] Angelin Philip, PhD student, GPM, CHLS, HBKU (Fall 2020 - ongoing)
Publications from BiswasLab at CHLS/HBKU:
[2] Asfia Sultana, PhD student, BBS, CHLS, HBKU (Fall 2020 - Spring 2024)
Publications from BiswasLab at CHLS/HBKU:
Uddin et al, Tight Junctions in Inflammation and Cancer [Book chapter]
Sultana et al, Front Bioeng Biotechnol, 2024
[1] Wesam Ahmed, PhD student, BBS, CHLS, HBKU (Spring 2020 - Spring 2023)
Publications from BiswasLab at CHLS/HBKU:
Sultana et al, Front Bioeng Biotechnol, 2024
Masters students
Current
Former
[2] Asma Fatima, MS student, BBS, CHLS, HBKU (Fall 2021 - Spring 2022)
Publications:
A Genetically Encoded BRET-based SARS-CoV-2 Mpro Protease Activity Sensor, Geethakumari AM, Ahmed WS, Rasool S, Fatima A, Uddin SM Nasir, Aouida M, Biswas KH* Communications Chemistry [in press] [Biorxiv - Preprint DOI: 10.1101/2022.01.31.478460]
Regulation of Tight Junction by Cadherin Adhesion and its Implication in Inflammation and Cancer Uddin SM Nasir, Sultana A, Fatima A, Geethakumari AM, Biswas KH* Tight Junctions in Inflammation and Cancer Ajaz A. Bhat et al. (Eds): Book chapter
[1] Saad Rasool, MS student, GPM, CHLS, HBKU (Fall 2020 - Fall 2021)
Publications:
Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence, Altamash T, Ahmed W, Rasool S, Biswas KH* International Journal of Molecular Sciences 2021, 22(2), 677 DOI: 10.3390/ijms22020677
Role of actin cytoskeleton in E-cadherin-based cell-cell adhesion assembly and maintenance, Rasool S#, Geethakumari AM#, Biswas KH* Journal of the Indian Institute of Science 2021, 101(1): 51-62 DOI: 10.1007/s41745-020-00214-0 [Invited Review Article]
Engineering β-catenin-derived peptides for α-catenin binding Uddin SM Nasir#, Rasool S#, Geethakumari AM, Ahmed WS, Biswas KH* Emergent Materials 2024 https://doi.org/10.1007/s42247-024-00663-8
Masters student at HBKU interested in our laboratory may write to Dr. Biswas directly.
ROTATION students
[5] Asfia Sultana, PhD student, BBS, CHLS, HBKU (Fall 2020)
[4] Debora Nicaretta Mattei, MS student, BBS, CHLS, HBKU (Fall 2020)
[3] Wesam Ahmed, PhD student, BBS, CHLS, HBKU (Fall 2019)
[2] Lutfiye Yildiz Ozer, PhD student, BBS, CHLS, HBKU (Fall 2019)
[1] Nada Mohamed Kafour, MS student, BBS, CHLS, HBKU (Fall 2019)
ALUMNI
[4] Debora Nicaretta Mattei, MS student (rotation), BBS, CHLS, HBKU (Fall 2020)
[3] Dr. Tausif Altamash, Postdoctoral Fellow, CHLS, HBKU (Fall 2019 - Spring 2020)
Publications:
Intracellular Ionic Strength Sensing Using NanoLuc Bioluminescence, Altamash T, Ahmed W, Rasool S, Biswas KH* International Journal of Molecular Sciences 2021, 22(2), 677 DOI: 10.3390/ijms22020677
[2] Lutfiye Yildiz Ozer, PhD student (rotation), BBS, CHLS, HBKU (Fall 2019)
[1] Nada Mohamed Kafour, MS student (rotation), BBS, CHLS, HBKU (Fall 2019)